H4CBD: a promising alternative to HHC in cannabis derivatives?

According to Dr. Joachim Müllner (Psychiatrist)

The French National Agency for the Safety of Medicines and Health Products (ANSM) has just taken an important decision: a ban on HHC, a drug used in the treatment of cancer. derivative in cannabis. However, it would appear that another substance has already taken its place on the market: H4CBD. But what is H4CBD Exactly ? What are its benefits and risks? To answer these questions, we met Dr. Joachim Müllner, psychiatrist and member of Doctissimo's expert committee.

What is H4CBD and what are its effects?

THE H4CBD is a synthetic cannabinoid derivative CBD. It is created in the laboratory by hydrogenating the CBD molecules present in cannabis flowers. These flowers have a very low THC (tetrahydrocannabidiol) content, less than 0.3%, and a high level of CBD (cannabidiol) molecules.

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Why did the H4CBD replace the now banned HHC?

According to Dr. Joachim Müllner, to speak of H4CBD as a product that "replaces" the HHC is mainly the marketing slogan used by CBD sellers to promote H4CBD pending a possible adaptation of the legislation. Indeed, unlike the H4CBD, the HHC is a derivative of cannabis containing high concentrations of THC. It is obtained by hydrogenating THC molecules, not CBD. Unlike CBD, and most probably H4CBD HHC has effects similar to those of classic cannabis containing a high level of THC, which impair normal brain function.

Does the H4CBD molecule have an affinity 100 times greater than that of CBD?

When you do a search on the internet with the term “H4CBD”, you will find a large number of sites selling products promoting a “potency” 100 times greater than that of CBD. However, this is obviously a false claim, again used as a marketing strategy to deceive consumers and sell more. The international scientific community currently lacks data to confirm anything about this. All of these sites only reproduce a single study from 2006, which, to my knowledge, has not been reproduced since. This study demonstrated that H4CBD has a hundred times greater affinity for CB1 receptors than CBD molecules, but this obviously does not mean that the effect itself is 100 times greater than that of CBD. Additional studies on the effects of H4CBD and on its biochemistry are necessary to pronounce definitively.

What are the pros and cons of the H4CBD? Is the risk of addiction important?

According to Dr. Joachim Müllner, the scientific community still lacks perspective on H4CBD. However, it seems that this molecule produces effects similar to those of CBD, such as relaxation, calming and a feeling of well-being. However, some sources also mention a psychoactive effect which suggests that H4CBD may soon be categorized as a “dysleptic” psychotropic and therefore also banned.

The disadvantages of H4CBD therefore lie in this psychoactive effect, the intensity and content of which have yet to be specified. In addition, its consumption by inhaling smoke from the combustion of cannabis is strongly carcinogenic and can cause pulmonary pathologies.

As for the risk of dependence, it is currently unknown and still requires investigation. However, it should be remembered that CBD, unlike THC, is not addictive.

Will the H4CBD also be banned soon, in your opinion?

According to Dr. Joachim Müllner, this will depend on whether or not there is a “dysleptic” psychoactive effect that alters normal brain function. If this psychotropic were to cause disorders of attention, memory, executive functions or even the processing of sensory information by the brain, like THC, it is very likely that H4CBD will also be prohibited.

In short, it is important to continue to study and evaluate the effects of H4CBD and CBD as a whole. Scientific research is essential to better understand these substances and their health implications. In the meantime, it is essential to inform consumers in a clear and transparent way, so that they can make informed decisions about their use.

Scientific reference of the article
Comparative in vitro metabolism of the cannabinoids